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Angiogenesis
BTK inhibitor
FLT3 inhibitor
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Bcr-Abl inhibitor
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Syk inhibitor
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kit
kit
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CRM1 inhibitor
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OCT activator
ATPase activator
Sodium Channel antagonist
CFTR modulator
P-gp modulator
Ubiquitin
E3 Ligase inhibitor
DUB inhibitor
p97 inhibitor
E2 conjugating inhibitor
E1 Activating inhibitor
Recommends
more>>
Cat#
Goods Name
Description
CC3022
U-104
U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and
CA XII
with
K
i
of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.
CC8637
SRT3025 HCl
SRT3025 is an orally available small molecule activator of the
SIRT1
enzyme.
CC7486
6H05
6H05 is a selective, and allosteric inhibitor of oncogenic
K-Ras(G12C)
.
CC7285
PYR-41
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme
E1
, with no activity at E2.
CC4311
Chlorzoxazone
Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.
CC9327
ACY-738
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 with IC50 values of 1.7 nM, with respective average selectivity over class I HDACs being 100-fold.
CC7667
LY2857785
LY2857785 is a type I reversible and competitive ATP kinase inhibitor against
CDK9
(IC50=0.011 μM) and also inhibits other transcription kinases
CDK8
(IC50=0.016 μM) and
CDK7
(IC50=0.246 μM).
CC2636
Loperamide HCl
Loperamide HCl is a selective
μ-opioid receptor
agonist opioid with
K
i
of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or
CC4375
Azaperone
Azaperone crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of
Dopamine receptors
with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
CC7205
Oprozomib (ONX 0912)
Oprozomib (ONX 0912) is an orally bioavailable inhibitor for CT-L activity of
20S proteasome
β5/LMP7 with
IC50
of 36 nM/82 nM. Phase 1/2.
CC1957
Ranitidine Hydrochloride
Ranitidine is a
histamine H2-receptor
antagonist, used to treat stomach or intestinal ulcers.
CC7843
GSK269962 HCl
GSK269962 is a selective
ROCK(Rho-associated protein kinase)
inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
CC7577
CGP 57380
CGP 57380 is a potent
MNK1
inhibitor with
IC50
of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases.
CC1228
ZSTK474
ZSTK474 inhibits class I
PI3K
isoforms with
IC50
of 37 nM in a cell-free assay, mostly PI3Kδ. Phase1/2.
CC4206
Valganciclovir HCl
Valganciclovir HCl is a prodrug for ganciclovir with antiviral activity used to treat cytomegalovirus infections.
CC8351
Oclacitinib maleate
Oclacitinib is a novel inhibitor of
JAK
family members with
IC50
ranging from 10 to 99 nM and JAK1-dependent cytokines with
IC50
ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases.
CC7282
Marinopyrrole A (Maritoclax)
Marinopyrrole A (Maritoclax) is a selective
Mcl-1
antagonist. It binds to Mcl-1, but not Bcl-XL, and targets Mcl-1 for proteasomal degradation. Maritoclax disrupts the interaction between Bim and Mcl-1 with an
IC50
of 10.1 μM.
CC4706
Azelaic acid
Azelaic acid is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.
CC8170
GW9508
GW9508 is a potent and selective agonist for
FFA1 (GPR40)
with
pEC50
of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.
CC2097
Enalapril Maleate
Enalapril Maleate is an
angiotensin-converting enzyme (ACE)
inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
CC4675
Citric acid trilithium salt tetrahydrate
Citric acid trilithium salt tetrahydrate is a pharmaceutical and construction material. It is commonly used in HPLC gradient elution for quantification of amino acids.
CC7525
4EGI-1
4EGI-1 is a competitive
eIF4E/eIF4G
interaction inhibitor by binding to eIF4E with
K
D
of 25 μM.
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