Description：

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with K_D of 25 μM.

Chemical Information：

Molecular Weight (MW)		451.28
Formula		C18H12Cl2N4O4S
CAS No.		315706-13-9
Solubility (25°C) *	DMSO	90 mg/mL (199.43 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Tie2 Flt-1/3/4 c-Kit c-Met VEGFR2 Ret 14.3 nM 12 nM/11.3 nM/6 4.6 nM 1.3 nM 0.035 nM 4 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2159 mL	11.0796 mL	22.1592 mL
5 mM	0.4432 mL	2.2159 mL	4.4318 mL
10 mM	0.2216 mL	1.1080 mL	2.2159 mL
50 mM	0.0443 mL	0.2216 mL	0.4432 mL

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