Description：

CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases.

Chemical Information：

Molecular Weight (MW)		244.23
Formula		C11H9FN6
CAS No.		522629-08-9
Solubility (25°C) *	DMSO	48 mg/mL warmed (196.53 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

p-Abl1T315I u-Abl1native u-Abl1T315I p-Abl1native Abl1H396P 4 nM 0.8 nM 5 nM 2 nM 1.4 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	4.0945 mL	20.4725 mL	40.9450 mL
5 mM	0.8189 mL	4.0945 mL	8.1890 mL
10 mM	0.4095 mL	2.0473 mL	4.0945 mL
50 mM	0.0819 mL	0.4095 mL	0.8189 mL

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