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JAK/STAT
All Categories
Angiogenesis
BTK inhibitor
FLT3 inhibitor
FGFR inhibitor
Bcr-Abl inhibitor
HIF inhibitor
Syk inhibitor
VEGFR inhibitor
Src inhibitor
ALK inhibitor
EGFR inhibitor
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kit
kit
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Stem Cells & Wnt
Stemness kinase inhibitor
Wnt/beta-catenin inhibitor
Hedgehog/Smoothened antagonist
Gamma-secretase inhibitor
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Wnt/beta-catenin agonist
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P-gp inhibitor
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OCT activator
ATPase activator
Sodium Channel antagonist
CFTR modulator
P-gp modulator
Ubiquitin
E3 Ligase inhibitor
DUB inhibitor
p97 inhibitor
E2 conjugating inhibitor
E1 Activating inhibitor
JAK/STAT
STAT inhibitor
JAK inhibitor
Pim inhibitor
Goods List
Display:
Cat#
Goods Name
description
CC8133
Napabucasin
Napabucasin is an orally available
Stat3
and cancer cell stemness inhibitor.
CC2370
AZ 960
AZ 960 is a novel ATP competitive
JAK2
inhibitor with
IC50
and
K
i
of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3.
CC7192
XL019
XL019 is a potent and selective
JAK2
inhibitor with
IC50
of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1.
CC3186
Niclosamide
Niclosamide can inhibit
DNA replication
and inhibit
STAT3
with
IC50
of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologue
CC7260
AZD1208
AZD1208 is a potent, and orally available
Pim kinase
inhibitor with
IC50
of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. Phase 1.
CC8160
ZM 39923 HCl
ZM 39923 HCl is an
JAK1/3
inhibitor with
pIC50
of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
CC4338
Nifuroxazide
Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.
CC2318
AZD1480
AZD1480 is a novel ATP-competitive
JAK2
inhibitor with
IC50
of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.
CC2842
NVP-BSK805 2HCl
NVP-BSK805 2HCl is a potent and selective ATP-competitive
JAK2
inhibitor with
IC50
of 0.5 nM,>20-fold selectivity towards JAK1, JAK3 and TYK2.
CC3007
Baricitinib (LY3009104, INCB028050)
Baricitinib (LY3009104, INCB028050) is a selective
JAK1
and
JAK2
inhibitor with
IC50
of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Phase 3.
Total
48
records
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