Description：

AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.

Chemical Information：

Molecular Weight (MW)		348.77
Formula		C14H14ClFN8
CAS No.		935666-88-9
Solubility (25°C) *	DMSO	69 mg/mL warmed (197.83 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

HCV NS5B 1a HCV NS5B 1b 0.94 μM 1.2 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.8672 mL	14.3361 mL	28.6722 mL
5 mM	0.5734 mL	2.8672 mL	5.7344 mL
10 mM	0.2867 mL	1.4336 mL	2.8672 mL
50 mM	0.0573 mL	0.2867 mL	0.5734 mL

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