Description：

CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM in a cell-free assay. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.

Chemical Information：

Molecular Weight (MW)		419.91
Formula		C23H22ClN5O
CAS No.		405168-58-3
Solubility (25°C) *	DMSO	7 mg/mL (16.67 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

γ-secretase 5 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3815 mL	11.9073 mL	23.8146 mL
5 mM	0.4763 mL	2.3815 mL	4.7629 mL
10 mM	0.2381 mL	1.1907 mL	2.3815 mL
50 mM	0.0476 mL	0.2381 mL	0.4763 mL

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