Description：

CCT245737 is an orally active CHK1 inhibitor with The IC50 of 1.4 nM. It exhibits >1,000-fold selectivity against CHK2 and CDK1.

Chemical Information：

Molecular Weight (MW)		379.34
Formula		C16H16F3N7O
CAS No.		1489389-18-5
Solubility (25°C) *	DMSO	75 mg/mL warmed (197.71 mM)
	Water	Insoluble
	Alcohol	9 mg/mL warmed (23.72 mM)

Biological Activity：

Targets IC50

Mcl-1 Bfl-1 Bcl-B Bcl-2 Bcl-XL Bcl-W 0.79 μM 1.06 μM 0.66 μM 1.21 μM 1.47 μM 2.02 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.6362 mL	13.1808 mL	26.3616 mL
5 mM	0.5272 mL	2.6362 mL	5.2723 mL
10 mM	0.2636 mL	1.3181 mL	2.6362 mL
50 mM	0.0527 mL	0.2636 mL	0.5272 mL

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