HSP (e.g. HSP90) inhibitor_Cytoskeletal Signaling_Chem Catch, Global Inhibitor Store

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Tanespimycin (17-AAG)

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.

VER-50589 is a potent HSP90 inhibitor with IC50 of 21 nM for HSP90β.

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

XL888 is an ATP-competitive inhibitor of HSP90 with IC50 of 24 nM. Phase 1.

Alvespimycin (17-DMAG) HCl

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

Apoptozole is an inhibitor of heat shock protein 70(HSP70) and Hsc70. It induces caspase-dependent apoptosis.

BIIB021 is an orally available, fully synthetic small-molecule inhibitor of HSP90 with K_i and EC50 of 1.7 nM and 38 nM, respectively. Phase 2.

CH5138303 is an orally available Hsp90 inhibitor with K_d of 0.48 nM.

Ganetespib (STA-9090)

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.

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