Description：

EED226 is a potent, selective, and orally bioavailable a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor with an IC50 of 23.4 nM when the H3K27me0 peptide was used as substrate and an IC50 of 53.5 nM when the mononucleosome was used as the substrate. It directly binds to the H3K27me3 binding pocket of EED.

Chemical Information：

Molecular Weight (MW)		369.40
Formula		C17H15N5O3S
CAS No.		2083627-02-3
Solubility (25°C) *	DMSO	73 mg/mL warmed (197.61 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

cyclooxygenase

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.7071 mL	13.5355 mL	27.0709 mL
5 mM	0.5414 mL	2.7071 mL	5.4142 mL
10 mM	0.2707 mL	1.3535 mL	2.7071 mL
50 mM	0.0541 mL	0.2707 mL	0.5414 mL

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