Description：

E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.

Chemical Information：

Molecular Weight (MW)		317.34
Formula		C18H15N5O
CAS No.		1140964-99-3
Solubility (25°C) *	DMSO	4 mg/mL warmed (12.6 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.1512 mL	15.7560 mL	31.5119 mL
5 mM	0.6302 mL	3.1512 mL	6.3024 mL
10 mM	0.3151 mL	1.5756 mL	3.1512 mL
50 mM	0.0630 mL	0.3151 mL	0.6302 mL

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