Description：

Doramapimod (BIRB 796) is a pan-p38 MAPK inhibitor with IC50 of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with K_d of 0.1 nM in THP-1 cells, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2.

Chemical Information：

Molecular Weight (MW)		527.66
Formula		C31H37N5O3
CAS No.		285983-48-4
Solubility (25°C) *	DMSO	100 mg/mL (189.51 mM)
	Water	Insoluble
	Alcohol	100 mg/mL (189.51 mM)

Biological Activity：

Targets IC50

DAT 118 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8952 mL	9.4758 mL	18.9516 mL
5 mM	0.3790 mL	1.8952 mL	3.7903 mL
10 mM	0.1895 mL	0.9476 mL	1.8952 mL
50 mM	0.0379 mL	0.1895 mL	0.3790 mL

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