Description：

Dacomitinib (PF299804, PF299) is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay, effective against NSCLCs with EGFR or ERBB2 mutations (resistant to gefitinib) as well as those harboring the EGFR T790M mutation. Phase 2.

Chemical Information：

Molecular Weight (MW)		469.94
Formula		C24H25ClFN5O2
CAS No.		1110813-31-4
Solubility (25°C) *	DMSO	19 mg/mL (40.43 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

5-HT6 9.63 (pKi)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1279 mL	10.6397 mL	21.2793 mL
5 mM	0.4256 mL	2.1279 mL	4.2559 mL
10 mM	0.2128 mL	1.0640 mL	2.1279 mL
50 mM	0.0426 mL	0.2128 mL	0.4256 mL

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