Description：

Cryptotanshinone is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5.

Chemical Information：

Molecular Weight (MW)		296.36
Formula		C19H20O3
CAS No.		35825-57-1
Solubility (25°C) *	DMSO	5 mg/mL warmed (16.87 mM)
	Water	Insoluble
	Alcohol	1 mg/mL warmed (3.37 mM)

Biological Activity：

Targets IC50

ATM ATR mTOR DNA-PK 28 nM 35 nM 0.25 nM 118 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.3743 mL	16.8714 mL	33.7427 mL
5 mM	0.6749 mL	3.3743 mL	6.7485 mL
10 mM	0.3374 mL	1.6871 mL	3.3743 mL
50 mM	0.0675 mL	0.3374 mL	0.6749 mL

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