Description：

Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively.

Chemical Information：

Molecular Weight (MW)		450.34
Formula		C21H22Cl2FN5O
CAS No.		877399-52-5
Solubility (25°C) *	DMSO	9 mg/mL (19.98 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

H3-receptor 9.2 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2205 mL	11.1027 mL	22.2054 mL
5 mM	0.4441 mL	2.2205 mL	4.4411 mL
10 mM	0.2221 mL	1.1103 mL	2.2205 mL
50 mM	0.0444 mL	0.2221 mL	0.4441 mL

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