Description：

CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.

Chemical Information：

Molecular Weight (MW)		486.31
Formula		C20H17Cl2N9O2
CAS No.		252935-94-7
Solubility (25°C) *	DMSO	8 mg/mL warmed (16.45 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

mTOR 0.19 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0563 mL	10.2815 mL	20.5630 mL
5 mM	0.4113 mL	2.0563 mL	4.1126 mL
10 mM	0.2056 mL	1.0282 mL	2.0563 mL
50 mM	0.0411 mL	0.2056 mL	0.4113 mL

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