Description：

CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1.

Chemical Information：

Molecular Weight (MW)		356.38
Formula		C20H16N6O
CAS No.		1265229-25-1
Solubility (25°C) *	DMSO	71 mg/mL (199.22 mM)
	Water	Insoluble
	Alcohol	1 mg/mL warmed (2.8 mM)

Biological Activity：

Targets IC50

HSP90β HSP90α 30 nM (Ka) 30 nM (Ka)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.8060 mL	14.0300 mL	28.0599 mL
5 mM	0.5612 mL	2.8060 mL	5.6120 mL
10 mM	0.2806 mL	1.4030 mL	2.8060 mL
50 mM	0.0561 mL	0.2806 mL	0.5612 mL

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