Description：

CEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with K_d of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.

Chemical Information：

Molecular Weight (MW)		517.46
Formula		C24H22F3N5O5
CAS No.		1188910-76-0
Solubility (25°C) *	DMSO	9 mg/mL (17.39 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

ALK2 ALK3 5 nM 30 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9325 mL	9.6626 mL	19.3252 mL
5 mM	0.3865 mL	1.9325 mL	3.8650 mL
10 mM	0.1933 mL	0.9663 mL	1.9325 mL
50 mM	0.0387 mL	0.1933 mL	0.3865 mL

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