Description：

Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively.

Chemical Information：

Molecular Weight (MW)		501.51
Formula		C28H24FN3O5
CAS No.		849217-68-1
Solubility (25°C) *	DMSO	100 mg/mL (199.39 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9940 mL	9.9699 mL	19.9398 mL
5 mM	0.3988 mL	1.9940 mL	3.9880 mL
10 mM	0.1994 mL	0.9970 mL	1.9940 mL
50 mM	0.0399 mL	0.1994 mL	0.3988 mL

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