Description：

Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Phase 2.

Chemical Information：

Molecular Weight (MW)		410.39
Formula		C18H21F3N6O2
CAS No.		944396-07-0
Solubility (25°C) *	DMSO	82 mg/mL (199.8 mM)
	Water	Insoluble
	Alcohol	2 mg/mL (4.87 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.4367 mL	12.1835 mL	24.3671 mL
5 mM	0.4873 mL	2.4367 mL	4.8734 mL
10 mM	0.2437 mL	1.2184 mL	2.4367 mL
50 mM	0.0487 mL	0.2437 mL	0.4873 mL

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