Description：

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.

Chemical Information：

Molecular Weight (MW)		464.56
Formula		C29H28N4O2
CAS No.		1207293-36-4
Solubility (25°C) *	DMSO	19 mg/mL warmed (40.89 mM)
	Water	Insoluble
	Alcohol	1 mg/mL (2.15 mM)

Biological Activity：

Targets IC50

GPR119

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1526 mL	10.7629 mL	21.5257 mL
5 mM	0.4305 mL	2.1526 mL	4.3051 mL
10 mM	0.2153 mL	1.0763 mL	2.1526 mL
50 mM	0.0431 mL	0.2153 mL	0.4305 mL

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