Description：

BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM in cell-free assays, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2.

Chemical Information：

Molecular Weight (MW)		560.48
Formula		C26H31Cl2N7O3
CAS No.		872511-34-7
Solubility (25°C) *	DMSO	1 mg/mL warmed (1.78 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Topoisomerase IV 0.024-6 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7842 mL	8.9209 mL	17.8418 mL
5 mM	0.3568 mL	1.7842 mL	3.5684 mL
10 mM	0.1784 mL	0.8921 mL	1.7842 mL
50 mM	0.0357 mL	0.1784 mL	0.3568 mL

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