Description：

BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.

Chemical Information：

Molecular Weight (MW)		516.6
Formula		C29H35F3N2O3
CAS No.		1230487-00-9
Solubility (25°C) *	DMSO	100 mg/mL warmed (193.57 mM)
	Water	Insoluble
	Alcohol	44 mg/mL warmed (85.17 mM)

Biological Activity：

Targets IC50

VEGFR2 VEGFR1 VEGFR3 160 nM 170 nM 125 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9357 mL	9.6787 mL	19.3573 mL
5 mM	0.3871 mL	1.9357 mL	3.8715 mL
10 mM	0.1936 mL	0.9679 mL	1.9357 mL
50 mM	0.0387 mL	0.1936 mL	0.3871 mL

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