Description：

WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).

Chemical Information：

Molecular Weight (MW)		464.95
Formula		C24H25ClN6O2
CAS No.		1214265-56-1
Solubility (25°C) *	DMSO	93 mg/mL (200.02 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1508 mL	10.7538 mL	21.5077 mL
5 mM	0.4302 mL	2.1508 mL	4.3015 mL
10 mM	0.2151 mL	1.0754 mL	2.1508 mL
50 mM	0.0430 mL	0.2151 mL	0.4302 mL

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