Description：

WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).

Chemical Information：

Molecular Weight (MW)		495.53
Formula		C24H29N7O5
CAS No.		1062169-56-5
Solubility (25°C) *	DMSO	99 mg/mL (199.78 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0180 mL	10.0902 mL	20.1804 mL
5 mM	0.4036 mL	2.0180 mL	4.0361 mL
10 mM	0.2018 mL	1.0090 mL	2.0180 mL
50 mM	0.0404 mL	0.2018 mL	0.4036 mL

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