Description：

AZD8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ with IC50 of 4 nM and 12 nM, respectively. Phase 1.

Chemical Information：

Molecular Weight (MW)		457.47
Formula		C24H25F2N3O4
CAS No.		1627494-13-6
Solubility (25°C) *	DMSO	91 mg/mL warmed (198.92 mM)
	Water	Insoluble
	Alcohol	35 mg/mL warmed (76.5 mM)

Biological Activity：

Targets IC50

CDK4/Cyclin D1 CDK3/Cyclin E CDK5/p35 CDK6/Cyclin D3 CDK1/cyclin B CDK2/Cyclin A 100 nM 360 nM 13 nM 170 nM 210 nM 47 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1859 mL	10.9297 mL	21.8594 mL
5 mM	0.4372 mL	2.1859 mL	4.3719 mL
10 mM	0.2186 mL	1.0930 mL	2.1859 mL
50 mM	0.0437 mL	0.2186 mL	0.4372 mL

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