Description：

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.

Chemical Information：

Molecular Weight (MW)		465.54
Formula		C25H31N5O4
CAS No.		1009298-09-2
Solubility (25°C) *	DMSO	50 mg/mL warmed (107.4 mM)
	Water	Insoluble
	Alcohol	3 mg/mL (6.44 mM)

Biological Activity：

Targets IC50

p110γ p110β p110δ mTOR p110α 9 nM 113 nM 43 nM 157 nM 39 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1480 mL	10.7402 mL	21.4804 mL
5 mM	0.4296 mL	2.1480 mL	4.2961 mL
10 mM	0.2148 mL	1.0740 mL	2.1480 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL

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