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Description：
Tozasertib (VX-680, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. Phase 2.
Chemical Information：
Molecular Weight (MW) 464.59 Formula
C23H28N8OS
CAS No. 639089-54-6 Solubility (25°C) * DMSO 93 mg/mL (200.17 mM) Water Insoluble Alcohol Insoluble
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg 1 mM 2.1524 mL 10.7622 mL 21.5244 mL 5 mM 0.4305 mL 2.1524 mL 4.3049 mL 10 mM 0.2152 mL 1.0762 mL 2.1524 mL 50 mM 0.0430 mL 0.2152 mL 0.4305 mL
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