Description：

AZD3759 is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. Phase 1.

Chemical Information：

Molecular Weight (MW)		459.90
Formula		C22H23ClFN5O3
CAS No.		1626387-80-1
Solubility (25°C) *	DMSO	91 mg/mL (197.86 mM)
	Water	Insoluble
	Alcohol	20 mg/mL warmed (43.48 mM)

Biological Activity：

Targets IC50

PDGFRα FGFR1 VEGFR2 Src Abl 1.1 nM 2.2 nM 1.5 nM 5.4 nM 0.37 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1744 mL	10.8719 mL	21.7439 mL
5 mM	0.4349 mL	2.1744 mL	4.3488 mL
10 mM	0.2174 mL	1.0872 mL	2.1744 mL
50 mM	0.0435 mL	0.2174 mL	0.4349 mL

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