Description：

Rociletinib (CO-1686, AVL-301) is an irreversible, mutant-selective EGFR inhibitor with K_i of 21.5 nM and 303.3 nM for EGFR^L858R/T790M and EGFR^WT in cell-free assays, respectively. Phase 2.

Chemical Information：

Molecular Weight (MW)		555.55
Formula		C27H28F3N7O3
CAS No.		1374640-70-6
Solubility (25°C) *	DMSO	100 mg/mL (180.0 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8000 mL	9.0001 mL	18.0002 mL
5 mM	0.3600 mL	1.8000 mL	3.6000 mL
10 mM	0.1800 mL	0.9000 mL	1.8000 mL
50 mM	0.0360 mL	0.1800 mL	0.3600 mL

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