Description：

Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.

Chemical Information：

Molecular Weight (MW)		553.65
Formula		C25H23N5O2S.CH4O3S
CAS No.		138489-18-6
Solubility (25°C) *	DMSO	100 mg/mL (180.61 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8062 mL	9.0310 mL	18.0620 mL
5 mM	0.3612 mL	1.8062 mL	3.6124 mL
10 mM	0.1806 mL	0.9031 mL	1.8062 mL
50 mM	0.0361 mL	0.1806 mL	0.3612 mL

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