Description：

Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.

Chemical Information：

Molecular Weight (MW)		284.24
Formula		C15H9FN2O3
CAS No.		775304-57-9
Solubility (25°C) *	DMSO	57 mg/mL (200.53 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

PI3Kγ PI3Kα mTOR PI3Kδ PI3Kβ 5 nM 0.4 nM 12 nM 2 nM 0.6 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.5182 mL	17.5908 mL	35.1815 mL
5 mM	0.7036 mL	3.5182 mL	7.0363 mL
10 mM	0.3518 mL	1.7591 mL	3.5182 mL
50 mM	0.0704 mL	0.3518 mL	0.7036 mL

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