Description：

AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl(T315I). Phase 2.

Chemical Information：

Molecular Weight (MW)		381.43
Formula		C19H23N7O2
CAS No.		896466-04-9
Solubility (25°C) *	DMSO	76 mg/mL (199.25 mM)
	Water	Insoluble
	Alcohol	38 mg/mL (99.62 mM)

Biological Activity：

Targets IC50

Angiotensin II 20 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.6217 mL	13.1086 mL	26.2171 mL
5 mM	0.5243 mL	2.6217 mL	5.2434 mL
10 mM	0.2622 mL	1.3109 mL	2.6217 mL
50 mM	0.0524 mL	0.2622 mL	0.5243 mL

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