Description：

AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2.

Chemical Information：

Molecular Weight (MW)		418.71
Formula		C16H18Cl3N5O2
CAS No.		902135-91-5
Solubility (25°C) *	DMSO	52 mg/mL warmed (124.19 mM)
	Water	43 mg/mL warmed (102.69 mM)
	Alcohol	28 mg/mL warmed (66.87 mM)

Biological Activity：

Targets IC50

PI3Kδ PI3Kγ 235 nM 83 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3883 mL	11.9414 mL	23.8829 mL
5 mM	0.4777 mL	2.3883 mL	4.7766 mL
10 mM	0.2388 mL	1.1941 mL	2.3883 mL
50 mM	0.0478 mL	0.2388 mL	0.4777 mL

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