Description：

Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with K_i of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.

Chemical Information：

Molecular Weight (MW)		562.71
Formula		C30H42N8O3
CAS No.		1380288-87-8
Solubility (25°C) *	DMSO	100 mg/mL warmed (177.71 mM)
	Water	Insoluble
	Alcohol	92 mg/mL warmed (163.49 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7771 mL	8.8856 mL	17.7711 mL
5 mM	0.3554 mL	1.7771 mL	3.5542 mL
10 mM	0.1777 mL	0.8886 mL	1.7771 mL
50 mM	0.0355 mL	0.1777 mL	0.3554 mL

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