Description：

AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.

Chemical Information：

Molecular Weight (MW)		621.08
Formula		C24H18ClFN4O2,C7H8O3S
CAS No.		1050500-29-2
Solubility (25°C) *	DMSO	124 mg/mL (199.65 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

c-Met 9 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.6101 mL	8.0505 mL	16.1010 mL
5 mM	0.3220 mL	1.6101 mL	3.2202 mL
10 mM	0.1610 mL	0.8050 mL	1.6101 mL
50 mM	0.0322 mL	0.1610 mL	0.3220 mL

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