Description：

Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.

Chemical Information：

Molecular Weight (MW)		556.63
Formula		C31H33FN6O3
CAS No.		945614-12-0
Solubility (25°C) *	DMSO	100 mg/mL (179.65 mM)
	Water	Insoluble
	Alcohol	100 mg/mL (179.65 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7965 mL	8.9826 mL	17.9653 mL
5 mM	0.3593 mL	1.7965 mL	3.5931 mL
10 mM	0.1797 mL	0.8983 mL	1.7965 mL
50 mM	0.0359 mL	0.1797 mL	0.3593 mL

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