Description：

Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activity against p38delta or p38gamma isoforms.

Chemical Information：

Molecular Weight (MW)		406.38
Formula		C19H20F2N4O4
CAS No.		449811-01-2
Solubility (25°C) *	DMSO	81 mg/mL (199.32 mM)
	Water	Insoluble
	Alcohol	28 mg/mL (68.9 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.4608 mL	12.3038 mL	24.6075 mL
5 mM	0.4922 mL	2.4608 mL	4.9215 mL
10 mM	0.2461 mL	1.2304 mL	2.4608 mL
50 mM	0.0492 mL	0.2461 mL	0.4922 mL

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