Description：

ARS-853 is a selective, covalent inhibitor of KRAS(G12C) that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.

Chemical Information：

Molecular Weight (MW)		432.94
Formula		C22H29ClN4O3
CAS No.		1629268-00-3
Solubility (25°C) *	DMSO	86 mg/mL warmed (198.64 mM)
	Water	Insoluble
	Alcohol	1 mg/mL warmed (2.3 mM)

Biological Activity：

Targets IC50

MT1 receptor MT2 receptor MT receptor (ch 14 pM (Ki) 112 pM (Ki) 23.1 pM (Ki) [1

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3098 mL	11.5489 mL	23.0979 mL
5 mM	0.4620 mL	2.3098 mL	4.6196 mL
10 mM	0.2310 mL	1.1549 mL	2.3098 mL
50 mM	0.0462 mL	0.2310 mL	0.4620 mL

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