Description：

Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro.

Chemical Information：

Molecular Weight (MW)		495.02
Formula		C26H31ClN6O2
CAS No.		1508250-71-2
Solubility (25°C) *	DMSO	99 mg/mL (199.99 mM)
	Water	Insoluble
	Alcohol	99 mg/mL (199.99 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0201 mL	10.1006 mL	20.2012 mL
5 mM	0.4040 mL	2.0201 mL	4.0402 mL
10 mM	0.2020 mL	1.0101 mL	2.0201 mL
50 mM	0.0404 mL	0.2020 mL	0.4040 mL

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