Description：

Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with K_i of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.

Chemical Information：

Molecular Weight (MW)		974.61
Formula		C47H55ClF3N5O6S3
CAS No.		923564-51-6
Solubility (25°C) *	DMSO	100 mg/mL (102.6 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.0261 mL	5.1303 mL	10.2605 mL
5 mM	0.2052 mL	1.0261 mL	2.0521 mL
10 mM	0.1026 mL	0.5130 mL	1.0261 mL
50 mM	0.0205 mL	0.1026 mL	0.2052 mL

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