Description：

MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. Phase 1.

Chemical Information：

Molecular Weight (MW)		461.94
Formula		C22H21ClFN3O3S
CAS No.		1010085-13-8
Solubility (25°C) *	DMSO	92 mg/mL (199.16 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1648 mL	10.8239 mL	21.6478 mL
5 mM	0.4330 mL	2.1648 mL	4.3296 mL
10 mM	0.2165 mL	1.0824 mL	2.1648 mL
50 mM	0.0433 mL	0.2165 mL	0.4330 mL

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