Description：

A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases.

Chemical Information：

Molecular Weight (MW)		329.44
Formula		C19H27N3O2
CAS No.		1527503-11-2
Solubility (25°C) *	DMSO	65 mg/mL (197.3 mM)
	Water	Insoluble
	Alcohol	65 mg/mL (197.3 mM)

Biological Activity：

Targets IC50

c-Kit PDGFRα/β VEGFR1/2/3 FGFR1/3 Flt3 2 nM 210 nM/27 nM [1 10 nM/13 nM/8 n 8 nM/9 nM 1 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.0355 mL	15.1773 mL	30.3545 mL
5 mM	0.6071 mL	3.0355 mL	6.0709 mL
10 mM	0.3035 mL	1.5177 mL	3.0355 mL
50 mM	0.0607 mL	0.3035 mL	0.6071 mL

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