Description：

Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.

Chemical Information：

Molecular Weight (MW)		638.82
Formula		C27H31Br2ClN4O2
CAS No.		193275-84-2
Solubility (25°C) *	DMSO	127 mg/mL (198.8 mM)
	Water	Insoluble
	Alcohol	127 mg/mL (198.8 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.5654 mL	7.8269 mL	15.6539 mL
5 mM	0.3131 mL	1.5654 mL	3.1308 mL
10 mM	0.1565 mL	0.7827 mL	1.5654 mL
50 mM	0.0313 mL	0.1565 mL	0.3131 mL

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