Description：

KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.

Chemical Information：

Molecular Weight (MW)		355.31
Formula		C16H16F3N3O3
CAS No.		1333151-73-7
Solubility (25°C) *	DMSO	71 mg/mL (199.82 mM)
	Water	Insoluble
	Alcohol	71 mg/mL (199.82 mM)

Biological Activity：

Targets IC50

JAK3 TYK2 JAK1 FLT3 JAK2 520 nM 50 nM 1280 nM 22 nM 23 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.8144 mL	14.0722 mL	28.1444 mL
5 mM	0.5629 mL	2.8144 mL	5.6289 mL
10 mM	0.2814 mL	1.4072 mL	2.8144 mL
50 mM	0.0563 mL	0.2814 mL	0.5629 mL

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