Description：

Kobe0065 is H-Ras-cRaf1 interaction inhibitor, exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.

Chemical Information：

Molecular Weight (MW)		449.79
Formula		C15H11ClF3N5O4S
CAS No.		436133-68-5
Solubility (25°C) *	DMSO	89 mg/mL (197.87 mM)
	Water	Insoluble
	Alcohol	13 mg/mL (28.9 mM)

Biological Activity：

Targets IC50

O6-alkylguanine- 5 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2233 mL	11.1163 mL	22.2326 mL
5 mM	0.4447 mL	2.2233 mL	4.4465 mL
10 mM	0.2223 mL	1.1116 mL	2.2233 mL
50 mM	0.0445 mL	0.2223 mL	0.4447 mL

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