Description：

Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.

Chemical Information：

Molecular Weight (MW)		283.33
Formula		C16H17N3O2
CAS No.		69408-81-7
Solubility (25°C) *	DMSO	57 mg/mL (201.17 mM)
	Water	Insoluble
	Alcohol	4 mg/mL (14.11 mM)

Biological Activity：

Targets IC50

HSP90 1.7 nM (Ki) and

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.5295 mL	17.6473 mL	35.2945 mL
5 mM	0.7059 mL	3.5295 mL	7.0589 mL
10 mM	0.3529 mL	1.7647 mL	3.5295 mL
50 mM	0.0706 mL	0.3529 mL	0.7059 mL

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