Description：

MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and K_i of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Phase 3.

Chemical Information：

Molecular Weight (MW)		361.03
Formula		C14H19BCl2N2O4
CAS No.		1072833-77-2
Solubility (25°C) *	DMSO	72 mg/mL (199.42 mM)
	Water	Insoluble
	Alcohol	9 mg/mL (24.92 mM)

Biological Activity：

Targets IC50

CB1 0.7 nM (Ki)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.7699 mL	13.8493 mL	27.6985 mL
5 mM	0.5540 mL	2.7699 mL	5.5397 mL
10 mM	0.2770 mL	1.3849 mL	2.7699 mL
50 mM	0.0554 mL	0.2770 mL	0.5540 mL

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