Description：

IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

Chemical Information：

Molecular Weight (MW)		409.44
Formula		C25H19N3O3
CAS No.		1127442-82-3
Solubility (25°C) *	DMSO	21 mg/mL (51.28 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

EGFR 35 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.4424 mL	12.2118 mL	24.4236 mL
5 mM	0.4885 mL	2.4424 mL	4.8847 mL
10 mM	0.2442 mL	1.2212 mL	2.4424 mL
50 mM	0.0488 mL	0.2442 mL	0.4885 mL

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