Description：

IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses.

Chemical Information：

Molecular Weight (MW)		466.6
Formula		C22H18N4O2S3
CAS No.		686770-61-6
Solubility (25°C) *	DMSO	4 mg/mL warmed (8.57 mM)
	Water	Insoluble
	Alcohol

Biological Activity：

Targets IC50

ATR 13 nM/26 nM (Ki

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1432 mL	10.7158 mL	21.4316 mL
5 mM	0.4286 mL	2.1432 mL	4.2863 mL
10 mM	0.2143 mL	1.0716 mL	2.1432 mL
50 mM	0.0429 mL	0.2143 mL	0.4286 mL

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