Description：

ARRY-380 (ONT-380) is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity.

Chemical Information：

Molecular Weight (MW)		480.52
Formula		C26H24N8O2
CAS No.		937263-43-9
Solubility (25°C) *	DMSO	96 mg/mL (199.78 mM)
	Water	Insoluble
	Alcohol	15 mg/mL (31.21 mM)

Biological Activity：

Targets IC50

PARP 20 nM (EC50) [1

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0811 mL	10.4054 mL	20.8108 mL
5 mM	0.4162 mL	2.0811 mL	4.1622 mL
10 mM	0.2081 mL	1.0405 mL	2.0811 mL
50 mM	0.0416 mL	0.2081 mL	0.4162 mL

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